“Personalization” of Crohn’s makes it challenging
Crohn’s Disease is an incurable, chronic, unpredictable, autoimmune Inflammatory Bowel Disease (IBD) which typically causes painful inflammation of any part of the digestive tract, i.e., from the mouth to the anus. Crohn’s Disease may affect as many as 700,000 Americans but it is also a “broad spectrum” disease in terms of its severity and pervasiveness. This means that while one Crohn’s patient can have 10+ abdominal surgeries, go to the bathroom 50 times a day and amass 100+ hospitalizations, another may never see the inside of a hospital and the disease will never be anything more than a minor inconvenience. The ostensibly “personalization” of Crohn’s Disease often makes it very difficult to diagnose, even harder to successfully treat and extremely challenging to manage.
Your overactive immune system attacks itself in Crohn’s
When you have an autoimmune disease like Crohn’s, your body’s immune system is unusually over-active and it mistakenly attacks itself (researchers believe this is caused by a combination of genetic, hereditary and environmental factors), causing inflammation in the gastrointestinal (or digestive) track. This inflammation of the intestinal walls causes a “narrowing” which makes it extremely painful to “pass” food and sometimes even liquids. In some cases, the inflammation from Crohn’s Disease damages the lining of the intestine so that it cannot absorb nutrients, water, and fats from food eaten and then digested. Surgical removal of parts of the intestine can also cause this problem, which is generally referred to as mal-absorption. This can result in malnutrition, dehydration, vitamin and mineral deficiencies, gallstones and kidney stones. Among younger children, mal-absorption, and/or the side effects of the more successful and potent drugs used to control Crohn’s Disease may also delay growth and development thereby making Adolescent Crohn’s Disease even more challenging.
Surgery for Crohn’s often just begets more surgery
In extreme cases, the intestinal inflammation caused by Crohn’s Disease can block the digestive passageway and cause an “obstruction” like water trying to pass through a fully bent “kink” in a garden hose. To avoid a life-threatening perforation of the bowel and lessen severe pain commonly compared to a pregnant woman’s most horrific labor pains, surgical intervention is often required to clear the obstruction or widen the narrowing by removing diseased portions of the intestine or the blocking scar tissue (strictures) which has formed from recurrent inflammation and/or from prior surgeries. That said, Crohn’s Disease can be chronic and aggressive such that intestinal inflammation can return days or weeks after such a life-saving surgery so surgery is a last resort for suffering patients. Making matters worse, surgical intervention is generally ill-advised for Crohn’s Disease patients because it typically leaves scar tissue or adhesions creating a situation where surgery for any reason usually begets more surgery. The bottom line is that doctors treating Crohn’s Disease patients are often faced with choosing the lesser of two (2) evils, and they must also consider the long-term effects since a patient has only so much bowel to remove.
Colostomies, Ileostomies and a J-Pouch
In other extreme cases, it is necessary to create an Ostomy which refers to the surgically created opening in the body for the discharge of body wastes. These typically include colostomies, ileostomies and a J-pouch procedure during which the colon and most of the rectum are surgically removed and an internal pouch is formed out of the terminal portion of the ileum. An opening at the bottom of this pouch is attached to the anus such that the existing anal sphincter muscles are used for continence. Just like with surgical options, creation of an ostomy is a treatment of last resort so before any ostomy is considered, much patient suffering occurs while a variety of non-surgical treatments are attempted.
Fistulas, Anal Fissures and Abscesses
If the inflammation caused by Crohn’s Disease in one area of the digestive tract spreads all the way through the intestinal wall, the inflamed area can literally “stick to” other organs and structures in and out of the abdominal area of the body. This leads to the formation of “fistulas” which can develop between the intestine and the other organs and structures it is not normally connected to; such as between different parts of the bowel, the bladder, the vagina, or even the skin on the outside of the body. This is obviously serious and requires immediate medical attention because the contents of the intestine can enter into these other sites, causing infection and other medical problems. Crohn’s Disease can also cause complications around the anus. These may include painful cracks in the skin known as “anal fissures” (i.e., a tear in the lining of the lower rectum (anus) that causes pain during bowel movements) or an “abscess,” a tender pocket of inflamed or dead tissue or pus that is also usually very painful.
If the Disease don’t getch ya’, the drugs will!
In addition to the above potentially serious, painful and disabling medical problems inherent in Crohn’s Disease, the often potent medications used to control the disease, such as Biologics, Prednisone, Methotrexate, Imuran, Budesonide, 6-MP, Flagyl, etc., can have severe side effects such as causing various forms of cancer, osteoporosis, diabetes, cataracts, fatal lung fungal infections, chronic respiratory problems, dangerous liver conditions, pancreatitis, anxiety and extreme fatigue. Also, people who suffer for several years with one (1) incurable autoimmune disease like Crohn’s Disease often begin suffering from another incurable autoimmune disease such as Rheumatoid Arthritis or Lupus.
The bottom line is that Crohn’s Disease can have unpredictable and devastating physical, mental, emotional, financial, social, professional and familial effects. The potential pervasive effects of Crohn’s Disease can affect everything from your appearance to your diet to your lifestyle to your relationships and even to your choice of careers, that is, if it doesn’t disable you.